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Preclinical study on adverse reactions of xingnaojing injection

In a synchronous cultivation experiment at the polymyxin E MIC breakpoint concentration (4 g/mL) using 20 pre-identified susceptible strains and 20 resistant strains, no growth was observed in the susceptible strains

Dihydromyricetin attenuates cisplatin-induced acute kidney injury by reducing oxidative stress, inflammation and ferroptosis

Another drug repurposed is metformin (clinically used as an anti-diabetic) which is being used as an AMPK activator, currently in phase II clinical trials for CLL (ClinicalTrials.gov: NCT01750567) (105, 106)

On the other hand, the HIF-1/HIF-1 dimer, together with the signal transducer and activator of transcription 3 (STAT3), an inducer of HIF-1 stability, participate in the genetic transcription of VEGF by binding to its activator CBP/p300

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