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IGF-1 LR3, by contrast, acts directly on all tissues expressing IGF-1 receptors, producing less tissue selectivity

John David Henneberry-Fudge, MD, FRCPC

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While each system detoxifies specific peroxides via GPx or Prx, they share substrates and can compensate for one another when impaired

In a related study, when C57BL/6J mice, rendered diabetic by STZ, were treated for 8 weeks with GABA (250g/kg), blood glucose concentrations declined in concert with a ~3-fold increase in plasma insulin, yet plasma glucagon was unaltered