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The following indicates which peptide hormone is responsible for stimulating the synthesis of which steroid hormone: Luteinizing Hormone (LH): progesterone and testosterone Adrenocorticotropic hormone (ACTH): cortisol Follicle Stimulating Hormone (FSH): estradiol Angiotensin II/III: aldosterone Role of ACTH in Adrenal Steroid Hormone Synthesis ACTH is a 39 amino acid peptide that is derived by post-translational modification from the 241 amino acid proprotein, proopiomelanocortin, POMC

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4 From basic neuroscience discoveries to translational innovation In subjects suffering from MDD, plasma levels of LAC are decreased as compared to age- and sex-matched controls