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demonstrated that age-related somatic mtDNA mutations could lead to defects in OXPHOS function, alter metabolic patterns, and accelerate the development of intestinal cancer

However, VCA contains different tissue components, and muscle is a highly metabolically active tissue that is most susceptible to reperfusion injury

Initial stages of refinement employed the use of torsion-angle Non-Crystallographic Symmetry (NCS) restraints (Terwilliger, 2013), which were released at the final stages of refinement

doi: 10.3389/fphar.2025.1602581 Received 30 March 2025 Revised 25 June 2025 Accepted 29 September 2025 Published 19 November 2025 Volume 16 - 2025 Edited by Paolo Montuschi, Catholic University of the Sacred Heart, Italy Reviewed by Ruo Wang, Shanghai Jiao Tong University, China Dengyun Nie, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, China Updates Copyright 2025 Xie, Chen, Guo, Zeng and He

Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application

doi:10.1006/jmbi.1998.1927