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doi:10.1242/dmm.015362

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GSH (l--glutamyl-L-cysteinyl-glycine) synthesis is initiated by generation of -glutamylcysteine from glutamate and cysteine via the glutamate-cysteine ligase (GCL), and the subsequent addition of glycine by the activity of GSH synthetase (GSS) (Figure 1.3 and 3.4b) [101, 226, 297]

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Surprisingly, to prevent activated neutrophils from releasing their highly cytotoxic inflammatory mediators into the tissue environment and damaging surrounding tissues along the bloodstream, neutrophils spontaneously undergo apoptosis