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These findings reveal that the therapeutic benefit of PD1/PD-L1 blockade is highly dependent on preexisting T-cell infiltration, a finding that was subsequently confirmed to be a common basis for the responses to various immunotherapies, such as CTLA-4 blockade and ICT treatment [106]
Zhang H, Yi J, Kim E, et al
98: 1982-1990 Shakir MKM, Brooks DI, McAninch EA, et al
Ammonia-induced autophagy is independent of Ulk1/Ulk2 kinases
doi: 10.1016/j.freeradbiomed.2018.01.009
Veniamakis, E., et al
