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Animal studies have demonstrated that type 1 diabetes mellitus (T1DM) can lead to testicular atrophy, disruption of seminiferous tubule architecture, and impaired spermatogenesis through multiple mechanisms, including oxidative stress, apoptosis, endocrine dysregulation, autoimmune responses, and epigenetic alterations [4, 5]

doi: 10.22074/ijfs.2015.4234

Development of enzymatic probes of oxidative and nitrosative DNA damage caused by reactive nitrogen species

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[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Kamionkowski S, Shibli F, Ganocy S, Fass R