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This suggests that therapeutic research focusing on DYRK1A inhibition should, at least in part, also take care of the problem of CBS triplication, at the condition that these inhibitors are specific of DYRK1A and do not inhibit GSK3 as well, as our data suggest that GSK3 activation is needed to reduce Nrf2 activity and thus CBS expression

For samples for which the peak intensity was lower than the blank threshold, metabolites were annotated as not detected, and the threshold value was imputed for any statistical comparisons to enable an estimate of the fold change as applicable

Circularly permuted green fluorescent proteins engineered to sense Ca2+

Glaucoma: management and future perspectives for nanotechnology-based treatment modalities

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It is characterized by microglial activation and enhanced release of inflammatory factors, such as tumor necrosis factor (TNF-), IL-2, IL-10, IL-4, IL-6, and interferon , which contribute to neuronal injury and death [30, 31]
