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Interestingly, Pariset et al
That regulatory gap has real consequences
doi: 10.1530/EJE-15-0617
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Mitochondrial dysfunction increases ROS expression, inducing liver and kidney damage with vascular remodeling, which promotes inflammation that exacerbates liver conditions and damages tissue integrity
Mol Pharmacol 65:5507, PMID: 14978233 Coles BF, Kadlubar FF (2003) Detoxification of electrophilic compounds by glutathione S -transferase catalysis: determinants of individual response to chemical carcinogens and chemotherapeutic drugs
