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This supports its relevance in the cytoprotection/adaptive cytoprotection course, and possible use in therapy (4-16)

Treatment of adipocytes isolated from lean mice with leptin stimulates lipolytic activity (33)

However, IGF1 has no significant impact on muscle mitochondrial function, indicating that the deficiency of IGF1 in male mice has different roles on tissue mitochondrial function between the center and periphery circulation (Pharaoh et al., 2020)

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