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When proper folding fails, misfolded or unfolded proteins accumulate in the ER lumen, disrupting its function and initiating cellular stress responses

Such cells can migrate to inflamed tissues and perform regulatory roles, which has a calming effect on inflammatory reactions, indicating crosstalk between GM and B cells in other tissues and also conferring long-term anti-inflammatory benefits (228)

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"The new neurometabolic cascade of concussion." Neurosurgery , 75(S4)

Theyre kind of counterproductive from a mitochondrial energy production standpoint

Principles of Geriatric Medicine and Gerontology
