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Sprinzak, D

However, most evidence comes from in vitro and xenograft studies with small sample sizes, and SIRT1s function varies depending on the context, showing both tumor-promoting and tumor-suppressing effects based on the upstream miRNA/lncRNA environment and experimental setup

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J Pediatr 175:206210

The last effect is important since it avoids any artificial reduction of GSSG to GSH during sample handling as the consequence of the shift to the right of the equilibrium (1): Therefore, the reaction of NEM with SH groups is so rapid and effective that any perturbation of the GSH-GSSG equilibrium is avoided