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Central to this process in ferroptosis is acyl-CoA synthetase long chain member 4 (ACSL4), which catalyzes the formation of arachidonic acid acyl-coA derivatives [92,93,94,95]

[DOI] [PubMed] [Google Scholar] 65.Meacham C.E., DeVilbiss A.W., Morrison S.J

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The resulting cysteine is unstable at extracellular level, and it is rapidly autoxidizes to cystine