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The proposed mechanism involves inhibiting serotonin reuptake in synapses, thereby prolonging elevated levels and enhancing its positive impact on mood regulation

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For example, ADCC mediated by daratumumab against primary MM cells was 14.2% in cells within the lowest tertile of CD38 expression vs

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In most of the patients who experienced flares, restarting the biologic treatment resulted again in disease remission, while concomitant immunomodulators may attenuate potential biologic immunogenicity

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