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Chiocchetti, R

These high-resolution spatial transcriptomics maps provide further support for the conclusions from the scRNA-seq results that a senescent-like MuSC and progenitor cell population is more abundant in the geriatric mice, suggesting stalled stem cell self-renewal in aging

In a recent proof-of-concept study performed in 40 patients with IBS, we showed that Lactobacillus paracasei CNCM I-1572 improves IBS symptoms through a significant reduction in genus Ruminococcus associated with a reduction of IL-15, linked with the modulation of IEB, and a significant increase in the fecal SCFAs acetate and butyrate (201)

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Specifically, an increase in Wnt5a and Wnt7 levels restricted to hippocampal granule cells level after spatial learning is observed whereas the Wnt3 level remains unchanged [96]