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Fe 3+ has been found in the senile plaques and NFT of AD patients where it is abundantly localized in neocortical grey matter, amygdale and olfactory tract [211-213]

G6PD Mediterranean is not homogeneous, but is composed of several distinct mutations, which G6PD Mediterranean (c.C563T) predominates

T.VarelaR

While the role of NRF-2 has been proven in hepatic pathogenesis and it has been established as a potential therapeutic target, it is at present under worldwide researches.AbbreviationsAMPK-PGC-1 Activated protein kinase coactivator 1 alpha ARE antioxidant response element CLD chronic liver disease CYP cytochromes GST glutathione S transferase GSH glutathione HFD high fat diet HO-1 heme oxygenase 1 iNOS inducible form of nitric-oxid Synthase JAK2 janus kinasa 2 KEAP1 Kelch-like ECH associating protein-1 PTEN liver specific phosphatase and tensin homology UPRmt mitochondrial unfolded protein Response NAFLD nonalcoholic fatty liver disease NASH nonalcoholic steatohepatitis NRF-2 nuclear factor (erythroid-derived 2)-like 2 PGC-1a peroxisome proliferator-activated PTENLKO PTEN deletion mice RNS reactive nitrogen species ROS reactive oxygen species STAT5 signal transducer and activator of transcription 5 SIRT-1 sirtuine 1 SREBP-1 sterol regulatory element-binding protein-1 TRX thioredoxin-dependent enzymes UPR unfolded protein response Conflict of interest The authors have no conflicts of interest to declare whatsoever

R., Lwe, J

Qu J, Sun M, Wang X, Song X, He H, Huan Y