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Cartilage & Joint Research Kwon and Park, Annals of Clinical and Laboratory Science (2015) Kwon and Park investigated the chondroprotective effects of intra-articular AOD-9604 administration in a rabbit model of osteoarthritis, with and without co-administration of hyaluronic acid

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NNMT depletes cells of NAD+, a crucial coenzyme required for mitochondrial function and energy production

Instead, AOD 9604 is used to study downstream metabolic signaling, particularly adipose tissue lipolysis, allowing researchers to isolate lipid metabolism pathways without engaging the broader endocrine GHIGF-1 axis