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Although primarily known as a pro-inflammatory cytokine that binds to cell membrane receptors to potentiate intracellular signaling 45 , eNAMPT can also be taken up by cells such as neurons and increase NAD + synthesis 46

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Cagrilintide activates the amylin receptor (a CALCR-RAMP complex), contributing gastric-emptying delay, central appetite suppression through area postrema activation, and glucagon inhibition

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