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This study was funded by the Shandong Province Modern Agricultural Technology System Donkey Industrial Innovation Team (grant number SDAIT-27), Livestock and Poultry Breeding Industry Project of the Ministry of Agriculture and Rural Affairs (grant number 19211162), Shandong Rural Revitalization Science and Technology Innovation Action Plan (Key Technology Innovation and Demonstration of Integrated Development of Dong-E Black Donkey Industry (grant number 2021TZXD012), Open Project of Liaocheng University Animal Husbandry Discipline (grant number 31931210114), Open Project of Shandong Collaborative Innovation Center for Donkey Industry Technology (grant number 3193308), Research on Donkey Pregnancy Improvement (grant number K20LC0901), and Liaocheng University Scientific Research Fund (grant number 318052025)

Additionally, mitragynine (10 M) inhibited digoxin transport in Caco-2 cell monolayers to the same extent as the clinically relevant P-gp inhibitor quinidine (Rusli et al., 2019)

By 2020, a total of K890 million (K10 million per open MP) was allocated to DSIPs, comprising 15 percent of PNGs capital expenditure (CDFs were 48 percent of Solomon Islands capital expenditure)

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The PI3K/Akt pathway, as a core anti-apoptotic regulatory axis, plays a key role in maintaining the integrity of the intestinal barrier by regulating effector molecules, such as Bcl-2 family proteins and caspase-3 ( Citrus unshiu peel (Chen pi) water extract (CUP) upregulated the expression of anti-apoptotic proteins Bcl-2 and Survivin by significantly inhibiting the expression of pro-apoptotic proteins Bax and caspase-3 in colonic tissues