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Figure 1 4 Role of cell senescence in vascular calcification: insights from chronic kidney disease In 1989, Professor Virchow first introduced a captivating discovery: individuals suffering from CKD manifest the same pathological transformations of medial calcification commonly observed in the elderly population (53)

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In fact, the targeting of TAM in cancer is well suitable for those types of tumors with a high proportion of these immune cells whose polarization decide the overall tumoral microenvironment

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However, there are still several outstanding issues in this area that have not been adequately addressed