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Description
The liver is the central organ that predominantly synthesizes GSH and secretes it into the bloodstream (Figure 1)

Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation

Under hyperglycemic conditions, dysfunction of the mitochondrial electron transport chain (ETC.) leads to excessive ROS production, subsequently inducing oxidative damage, mitochondrial DNA (mtDNA) mutations/leakage, and activation of inflammatory pathways such as the NLR family pyrin domain containing 3 (NLRP3) inflammasome and the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING), thereby exacerbating local and systemic inflammation and hindering wound healing (Wang et al., 2025a

Cold Intolerance: Increased sensitivity to cold temperatures
Cao, Z., Subramaniam, S

Journal of preventive medicine and public health = Yebang Uihakhoe chi