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The answer is illustrated in the following figures and it could be explained as follows: If the value for k a increased (0.3 to 0.7/hr) while the elimination rate is kept constant, then t max becomes shorter, C max increases, and AUC remains constant

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We investigated potential technical and biological confounders, observing little correlation between these variables and heteroplasmies (Extended Data Fig

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These results suggest that the process of iron chelation can potentially help in preventing the apoptosis of chondrocytes and the destruction of the cartilage extracellular matrix