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26,27 Since most organic materials have hydrophobic structures and tend to aggregate in an aqueous physiological environment, the ACQ effect has greatly limited their applications in biological systems

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It was first identified in pathogenic Neisseria species but its homologs have now been found in several medically significant human pathogens, including H

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In this section, examples of diseases and normal physiologic events that involve Glu and Gln alteration as assessed with in vivo MRS are discussed