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Recently, studies have shown that the central nervous system (CNS) is related to the gastrointestinal tract through the brain-gut axis, which originates from the brainstem and spinal cord and innervates the intestines through the vagus nerve, splanchnic nerve, mesenteric nerve and pelvic spinal cord nerve [40, 41]

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Ultimately, after being released into the synaptic space, it is taken up by surrounding neurons and glia, resulting in neurodegeneration (Peng et al., 2018)

In KO mice, two major lipogenic genes, Fasn and Scd1 , were suppressed by EtOH, whereas Acox1 was induced (Fig

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