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For instance, pachymaran (PCP), the major constituent of Poria cocos , activates the Nrf2/ARE pathway, upregulates HO-1 and NQO1 gene expression, enhances intrinsic antioxidant capacity, and suppresses TLR4/NF-B signaling to reduce inflammatory mediator release (70)

Inflammatory cells during wound repair: The good, the bad and the ugly
Sung et al., 2009) and also respond to light and some stress conditions such as drought and certain pathogens (Figure 3B)

Easter, R.A., P.A

86 (4 Suppl

10.1016/j.it.2009.09.002 144
