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Inspiratory bursts were recognized as large amplitude integrated signals with a frequency of 0.020.3 Hz, confirmed in some cases by observing synchronous bilateral bursts from a second electrode placed over the contralateral preBtC

Two predominant hypotheses have emerged: the outside-in model, where peripheral immune activation drives CNS demyelination, and the inside-out model, which posits that primary glial or axonal injury triggers the disease