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Comprised of TXN, thioredoxin reductase (TrxR), and nicotinamide adenine dinucleotide phosphate (NADPH), this system facilitates the reduction of oxidative GSH to its active form in response to NADPH [78], thereby supporting the removal of cytotoxic GSH by GPX4 [79, 80]

This hypothalamic factor exerts its action in the pituitary cells through the activation of GPCRs and the signaling by PLC and cAMP pathways (222, 223)

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doi: 10.1016/j.foodcont.2018.02.032 76 LoiM.FanelliF.ZuccaP.LiuzziV

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