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Findings from the Framingham Heart Study, a large community-based cohort including offspring and third-generation participants, revealed that choline intake, calculated as the sum of dietary choline-containing compounds including phosphocholine, sphingomyelin, free choline, glycerophosphocholine, and PC, was inversely associated with NAFLD risk (159)

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It can resemble a melanotic macule, showing melanin accumulation in the basal cell layer, or it may result from the deposition of drug-related metabolites as fine brown-yellow granules within the lamina propria [11,12]