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Statistical analyses were performed using GraphPad Prism version 5.0 (La Jolla, CA, USA)

In the fasting state, normal mitochondria preferentially oxidize fatty-acids, and mitochondrial function is impaired in aging (17,21)

Similarly, Robert and collaborators observed a marked reduction in the number of peritumoral neurons in mice bearing Sxc -expressing gliomas compared to animals implanted with gliomas lacking Sxc [53]

Ryan et al., 2013

Metabolism 64(6):720728

Both have similar biological effects that are caused by binding to the IGF-1 receptor (IGF-1R), whereas the IGF-2R is specific for IGF-2 and thought to have no physiological role except serving to degrade IGF-2 28 (Figure 1)