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Daratumumab (DARA), a CD38-targeting IgG1 mAb approved for MM therapy in 2015 (U.S.) and 2016 (EU), was from Janssen Pharmaceuticals, while isatuximab (ISA) was from Sanofi (62)

Metabolite differences between CFS and healthy controls achieved diagnostic accuracies of 94% in males, and 96% in females

The Neelakantan 2018 paper showed strong oral absorption in cell uptake (Caco-2) assays, which is why most research community use is by mouth instead of by injection

In a comprehensive PMOS plan addressing gut health and inflammation, it may have a role under clinical supervision

Note: Published findings for these peptides are predominantly preclinical and should be interpreted within the limits of the model system used

Each indication requires its own evidence base