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Modern studies indicate that licorice can inhibit the intestinal absorption of diester diterpene alkaloids from Aconitum species and promote their metabolism and excretion through the induction or regulation of drug-metabolizing enzymes and efflux transporters, thereby mitigating toxicity [39]

In contrast, in this experimental murine model of NASH induced by an MCD diet, supplementation with a mixture of n-3 PUFAs (EPA and DHA) in olive oil significantly exacerbated hepatic inflammation compared to supplementation with olive oil alone (Provenzano et al., 2014)

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Hyperinsulinemia, a common feature of PCOS, exacerbates this process by upregulating transferrin receptor 1 (TFR1), thereby enhancing cellular iron uptake

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