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Cause [edit] The exact cause of primary sclerosing cholangitis is unknown, and its pathogenesis is improperly understood

Open-label, randomized phase II trial with BNT111 and cemiplimab in combination or as single agents in patients with Anti-PD-1-refractory/Relapsed, unresectable stage III or IV melanoma (2020)

Surgical procedures or conditions that affect the gut, such as gastric bypass surgery or celiac disease, can prevent intrinsic factors from binding to B12 and prevent the body from breaking it down before absorbing the vitamin

In the Netherlands ambulances, fire departments and emergency rooms have the Cyanokit at their disposal

Emerging multi-objective frameworks, including AB-Gen and AntBO, aim to address these challenges by concurrently optimizing for binding efficacy, stability, immunogenicity and manufacturability

When NNMT consumes NAD+ faster than it can be replenished, even well-functioning mitochondria can't maintain oxidative phosphorylation at optimal rates