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nAChRs help communicate signals resulting in muscle contraction

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By integrating findings from animal models, clinical imaging, and molecular biology, this work elucidates how dysfunctions in GABAergic interneurons (e.g., PV+, SST+, VIP+), GABA signaling pathways, and associated genes collectively disrupt the E/I balance in the brain, leading to core ASD symptoms such as social communication deficits, repetitive behaviors, and sensory abnormalities

Hexachlorobutadiene, utilized in the rubber industry and pesticide manufacturing, produces metabolites that accumulate in bladder cells and induce gene mutations by binding to DNA, thus posing a potential risk for bladder cancer (Zhang et al., 2019