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Exposure to toxins such as cigarette smoke, air pollution, and heavy metals can also deplete glutathione levels. The Role of Glutathione in Alcohol Metabolism Glutathione plays a crucial role in the metabolism and detoxification of alcohol by helping eliminate acetaldehyde, a toxic byproduct

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The and classes of GSTs play a regulatory role in the mitogen-activated protein (MAP) kinase pathway that participates in cellular survival and death signals via protein:protein interactions with c-Jun N-terminal kinase 1 (JNK1) and ASK1 (apoptosis signal-regulating kinase)