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Data in literature suggest that the linkage of these RBC cytosolic enzymes to the membrane is triggered by metabolic stress, possibly, to protect the erythrocyte membrane and counteract the effects of OS

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Choi YJ, Seelbach MJ, Pu H et al (2010) Polychlorinated biphenyls disrupt intestinal integrity via NADPH oxidase-induced alterations of tight junction protein expression

Sleep Med 5:523532 Uchida K, Okamoto N, Ohara K, Morita Y (1996) Daily rhythm of serum melatonin in patients with dementia of the degenerate type

Furthermore, CHAC2 was upregulated in a model of APAP-induced hepatic damage following treatment with naringin (Zhai et al., 2022)