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By regulating the Ddx41/IFN-I signaling pathway, miR-218-5p effectively mitigates neuroinflammation caused by microglia, thereby preserving the integrity of DA neurons (Wang et al., 2024)

This ensures rapid, direct uptake by cells for immediate antioxidant and detoxifying activity

HOTAIR accelerates dyskinesia in a MPTP-lesioned mouse model of PD via SSTR1 methylation-mediated ERK1/2 axis

Treatment did not affect GSH but raised the plasma concentrations of serine, homocysteine, cysteine, and folate, which are 1-carbon cycle metabolites

Research protocols measuring acute NNMT inhibition kinetics benefit from IM's faster Tmax, allowing tighter correlation between dosing time and metabolic measurements