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PQ is principally reduced by Complex I in mitochondria, where PQ induces an increase in the Ca 2+ -dependent permeability of the mitochondrial membrane and forms superoxide

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Yu et al., 2017), while glycolysis is increased by EC stimulation with vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) inducing cellular proliferation and migration (Yu et al., 2017)

Effective drug-based therapy against these critical diseases is crucial

Overall, these reviewed studies underscore the emerging promise of phytocompounds as adjunctive or standalone interventions for MDD (Table 1)

Arch Agron Soil Sci 61:615626