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The difference between these two arginine metabolic pathways forms the basis of M1/M2 polarization of immune response

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The long-term use of certain peptide preparations led to significantly increased longevity (mean lifespan increases between 20% and 40%) as well as a slower rate of age-associated alterations to biomarkers linked to physical and mental decline

Another trial in 54 individuals confirmed its safety over 10 days of intravenous use at doses of up to 5.0g/kg (and up to 25.0g/kg in a single-dose trial)

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neuropeptide "psychosomatic network" hypothesis (J Immunol, 1985)