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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation
Side Effect 5: Systemic Effects Systemic reactions may include fatigue, anxiety, and numbness in extremities
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Handle using appropriate laboratory safety procedures and personal protective equipment

the term about refers to a 10% variation from the nominal value

Mol Nutr Food Res 2015;59:1364-1372