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Before diving into the mechanics of testing, it is essential to understand what we are actually measuring

The proteins on the beads were dissolved by using SDS-loading buffer, and enriched by SDS-PAGE

In literature, it is discussed whether this toxicity is related to the oxidative phase I metabolism, resulting in electrophilic quinone imines, which can subsequently react with nucleophiles present in the liver in form of glutathione or proteins

While the two doses significantly improved GPX levels, they did not quite reach normal values

These results suggest that PET particles at this concentration do not cause oxidative stress, but rather trigger a temporary mitochondrial dysfunction followed by recovery, likely through mitohormesis [133]

Antioxid Redox Signal 35(11):849862 Li Q, Chen C, Chen X, Han M, Li J (2018) Dexmedetomidine attenuates renal fibrosis via 2-adrenergic receptor-dependent inhibition of cellular senescence after renal ischemia/reperfusion