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Recently, diverse siRNAs capable of targeting four hotspot mutations, which account for approximately 20% of all p53 mutations, have been generated

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The results of Smiths study were very important, as the administration of PTX (400 mg, orally three times daily) was able, after 1.2 years, to reduce the volume of plaque calcifications by an average of 69.4%

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This could explain why tirzepatide (which stimulates the GIP pathway in addition to GLP -1) can be administered at higher doses than semaglutide (which only stimulates GLP-1), without amplifying the side effects typical of GLP-1 agonists (nausea, vomiting)