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Moreover, MSH3 deficiency demonstrates comprehensive therapeutic potential by correcting synaptic dysfunction, astrocytic abnormalities and locomotor deficits in HD mice ( MSH3 and PMS1 play pivotal roles in driving accelerated somatic mHTT CAG expansion rates specifically in HD-vulnerable neurons, underlying the repeat length-dependent, threshold-sensitive, selective and progressive pathogenesis in vivo

By regulating the Ddx41/IFN-I signaling pathway, miR-218-5p effectively mitigates neuroinflammation caused by microglia, thereby preserving the integrity of DA neurons (Wang et al., 2024)

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Journal of receptor and signal transduction research 25 , 181198 (2005)

Furthermore, the level of another metabolite, choline, as an integral marker of cell membrane myelin in brain tissue and a precursor of acetylcholine, is significantly elevated in DKD patients