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Genome editing technologies which have been successfully used to modify livestock phenotype through the introduction of useful alleles for heat tolerance, disease resistance (e.g., tuberculosis, mastitis, bovine respiratory disease), production (e.g., production of male-only offspring, myostatin gene knockout), elimination of allergens (e.g., beta-lactoglobulin gene knockout), and welfare (e.g., introduction of polled or hornlessness) into livestock populations [reviewed by Mueller et al

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