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Collagens are a major component of connective tissue such as cartilage, tendons, the organic matrix of bones, and the cornea of the eye

This was done by staining for ECM proteins (elastin, collagen type 1, and collagen type 3), followed by qualitative and quantitative histological image analyses

Therefore, the level of intracellular copper determines the activity of LOX

The underlying mechanisms of these two aging processes are intricate and distinct, encompassing various elements, including temporal aspects, genetic predisposition, immune responses, endocrine influences, and ultraviolet radiation

Public Health 2 , 145 (2014)