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100,101 Clinically, the TruFit Plug (Smith & Nephew, San Antonio TX) is one of the only synthetic osteochondral scaffolds that has been evaluated in patients, 102,103 with a subchondral phase containing calcium sulfate for bone regeneration and an articulating phase that relied on marrow stimulation for cartilage regeneration

The generation of oxygen radicals is normally mitigated by the presence of adequate endogenous antioxidant defenses [37]

In summary, Alzheimers diseaseassociated neurodegeneration is characterized by substrate depletion and diminished enzymatic efficiency, reflecting a broader dysregulation of energy metabolism

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For this reason, the homeostasis of extracellular glutamate is tightly controlled by the combined activity of neuronal and glial membrane transporters, such as glutamate transporter-1 (GLT1), glutamate aspartate transporter (GLAST), and the cysteine/glutamate antiporter, or system xc (Sxc ), present in astrocytes, and EAAT3 present in neurons

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