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The metabolic consequence of PK deficiency is a depletion of cellular ATP and an increase in 2,3-bisphosphoglycerate (2,3-BPG)

Melatonin prevents lung injury induced by hepatic ischemia-reperfusion through anti-inflammatory and anti-apoptosis effects

Furthermore, in the future, the upregulated activity of forkhead box O1 transcription factor (FoxO1) in DCM as studied from preclinical models (Shafaati and Gopal, 2024) would need further evaluation for biomarker and therapeutic targets in the clinical studies of DCM

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While B2m + OLs did not significantly differ between 5 weeks and 5 + 3 weeks ( p = 0.08), these trends suggest progressive emergence of immune-associated OL programs during recovery