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As a key cell signaling molecule, CO not only regulates vascular tone but also confers resistance to ER stress in endothelial cells by down-regulating CCAAT/enhancer-binding protein homologous protein expression and up-regulating the Nrf2/HO-1 pathway (Yang et al., 2014)

This oligomerization leads to protein toxic stress, ultimately inducing cell death

doi: 10.1016/j.redox.2022.102413

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By separating the lifetimes of emitted photons on a phasor plot (Fig

This is also the dose used for type 2 diabetes management under the Ozempic brand, and it represents the point where semaglutide is working at full therapeutic strength for blood sugar control