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Mitochondrial problems were present as early as P15 (postnatal day 15) 17 , and they were also observed in the upper motor neurons (UMNs) of a broad spectrum of ALS patients with TDP-43 pathology 16

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That became the first section of the book

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EMBO Rep 2005

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The pineal gland is best known for producing melatonin and for its role in circadian and seasonal rhythms, and mid-twentieth-century Soviet gerontology became interested in the idea that pineal factors might influence aging

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[PubMed: 10677054] 80

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