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Endothelial cell dysfunction, which is characterized by impaired endothelium-dependent vasodilation due to the compromised ability of endothelial cells to produce NO, constitutes a major cause of cardiovascular diseases [59]

189 In an uncontrolled trial that included 119 men with idiopathic infertility, supplementation with a multi-nutrient cocktail containing vitamins, minerals, and several antioxidants twice daily for three months led to significant improvements in sperm concentration, motility, morphology, and DNA fragmentation compared with pretreatment analyses

All in all, the p53-based immunotherapy approach has shown promise in inhibiting the PD-L1 immune checkpoint in various solid tumors