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Hypoxia is able to regulate glycolysis, glycogen synthesis, lipid metabolism and oxidative phosphorylation, thus playing a vital role in tumor cell survival and growth during all stages of metastasis (247)
Within this context, the PD-1/PD-L1 pathway is crucial in managing the exhaustion of T cells
The exception might be intravenous therapies like the MSC case, but even that was experimental
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Trx, thioredoxin
Hopefully yes, but not for some time
